Amfepramone

Amfepramone

Amfepramone (also known as diethylpropion) is a stimulant drug that is primarily used as an appetite suppressant. It is chemically related to amphetamines, which are a group of psychoactive drugs that stimulate the central nervous system and have effects on neurotransmitters in the brain. Amfepramone is prescribed for the short-term management of obesity, alongside diet, exercise, and behavior modification. It works by decreasing appetite and possibly increasing the amount of energy used by the body.

Medical Uses

Amfepramone is used as a short-term supplement to diet and exercise in the treatment of obesity. Its use is typically limited to a few weeks, as the effectiveness and safety of long-term use have not been established. It is indicated for individuals with an initial body mass index (BMI) of 30 kg/m² or higher, or 27 kg/m² or higher in the presence of other risk factors such as hypertension, diabetes, or dyslipidemia.

Mechanism of Action

The exact mechanism of action of amfepramone is not fully understood, but it is believed to work by stimulating the release of norepinephrine and dopamine, two neurotransmitters that play a role in appetite regulation. By increasing the levels of these neurotransmitters, amfepramone may reduce feelings of hunger.

Side Effects

Common side effects of amfepramone include insomnia, dry mouth, dizziness, and irritability. Because of its stimulant properties, it can also increase heart rate and blood pressure, making it unsuitable for individuals with pre-existing cardiovascular disease. The risk of dependence and abuse is also a concern with amfepramone, similar to other amphetamine-like drugs.

Contraindications

Amfepramone is contraindicated in individuals with a history of cardiovascular disease, hyperthyroidism, glaucoma, and in those who are currently using or have used monoamine oxidase inhibitors (MAOIs) within the previous 14 days. It should not be used in combination with other central nervous system stimulants.

Regulation

The legal status of amfepramone varies by country. In some places, it is classified as a controlled substance due to its potential for abuse and dependence. Prescribers and users must adhere to strict regulations to prevent misuse and ensure safety.