Adrenergic neuron blockers

Adrenergic neuron blockers are a class of drugs that inhibit the release of norepinephrine from adrenergic neurons. These drugs are primarily used in the treatment of hypertension and other cardiovascular disorders.

Mechanism of Action

Adrenergic neuron blockers work by blocking the release of norepinephrine from adrenergic neurons. This is achieved by inhibiting the uptake of tyrosine, which is a precursor to norepinephrine. By blocking the uptake of tyrosine, these drugs reduce the amount of norepinephrine that can be produced and released.

Clinical Uses

Adrenergic neuron blockers are primarily used in the treatment of hypertension. They can also be used to treat other cardiovascular disorders such as angina pectoris, arrhythmias, and heart failure. In addition, they can be used to manage symptoms of anxiety and panic disorder.

Side Effects

Common side effects of adrenergic neuron blockers include dizziness, fatigue, and nausea. In some cases, these drugs can also cause orthostatic hypotension, which is a drop in blood pressure when standing up from a sitting or lying position.

Examples

Examples of adrenergic neuron blockers include guanethidine, reserpine, and metyrosine.

See Also

• Adrenergic receptor
• Adrenergic agonist
• Adrenergic antagonist

References

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