Aetokthonotoxin

Aetokthonotoxin is a neurotoxin that is produced by the sea anemone Anthopleura elegantissima. It is a potent blocker of voltage-gated sodium channels in neurons, which can lead to paralysis and other neurological symptoms.

Structure and Function

Aetokthonotoxin is a protein composed of 48 amino acids. It has a compact, stable structure that is stabilized by three disulfide bonds. The toxin binds to voltage-gated sodium channels in neurons, blocking the flow of sodium ions into the cell. This prevents the neuron from firing, leading to paralysis and other neurological symptoms.

Toxicity

The toxicity of aetokthonotoxin is due to its ability to block voltage-gated sodium channels. This can lead to a variety of symptoms, including muscle weakness, numbness, and paralysis. In severe cases, it can cause respiratory failure and death.

Treatment

There is currently no specific antidote for aetokthonotoxin. Treatment is supportive and includes respiratory support and symptomatic treatment. Research is ongoing to develop specific antidotes and treatments for aetokthonotoxin poisoning.

See Also

• Neurotoxin
• Sea anemone
• Voltage-gated sodium channel

Aetokthonotoxin Resources
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