Alendronate sodium

Alendronate sodium

Alendronate sodium is a bisphosphonate medication used to treat and prevent osteoporosis in postmenopausal women and to treat osteoporosis in men. It is also used to treat Paget's disease of bone and glucocorticoid-induced osteoporosis. Alendronate sodium works by inhibiting osteoclast-mediated bone resorption, which leads to an overall increase in bone mineral density.

Medical Uses

Alendronate sodium is primarily prescribed for:

• Osteoporosis in postmenopausal women
• Osteoporosis in men
• Paget's disease of bone
• Glucocorticoid-induced osteoporosis

Mechanism of Action

Alendronate sodium belongs to the class of drugs known as bisphosphonates. It works by binding to hydroxyapatite found in bone, inhibiting the action of osteoclasts, the cells responsible for bone resorption. This inhibition reduces bone turnover, allowing for the maintenance or increase of bone density.

Administration

Alendronate sodium is typically administered orally, either daily or weekly, depending on the specific condition being treated. It is important to take the medication with a full glass of water and to remain upright for at least 30 minutes afterward to prevent esophageal irritation.

Side Effects

Common side effects of alendronate sodium include:

• Gastrointestinal discomfort
• Esophagitis
• Musculoskeletal pain
• Hypocalcemia

Rare but serious side effects may include:

• Osteonecrosis of the jaw
• Atypical femur fractures

Contraindications

Alendronate sodium is contraindicated in patients with:

• Esophageal abnormalities
• Inability to stand or sit upright for at least 30 minutes
• Hypocalcemia
• Renal impairment

Related Pages

• Bisphosphonate
• Osteoporosis
• Paget's disease of bone
• Osteoclast
• Bone mineral density