Allocation concealment

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The procedure for protecting the randomization process so that the treatment to be allocated is not known before the patient is entered into the study.

A technique used to prevent selection bias by concealing the allocation sequence from those assigning participants to intervention groups, until the moment of assignment. Allocation concealment prevents researchers from (unconsciously or otherwise) influencing which participants are assigned to a given intervention group.

The process used to ensure that the person deciding to enter a participant into a randomized controlled trial does not know the comparison group into which that individual will be allocated. This is distinct from blinding, and is aimed at preventing selection bias. Some attempts at concealing allocation are more prone to manipulation than others, and the method of allocation concealment is used as an assessment of the quality of a trial.

Allocation concealment Resources
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Contributors: Prab R. Tumpati, MD