Alpha-Bungarotoxin
Alpha-Bungarotoxin is a type of neurotoxin that is produced by the many-banded krait snake. It is a member of the three-finger toxin family and is known for its ability to block nicotinic acetylcholine receptors.
Structure[edit | edit source]
Alpha-Bungarotoxin is a protein that consists of 74 amino acid residues. It has a three-finger structure, which is common among snake venom toxins. The three loops extend out from a central core, and the tips of these loops contain the residues that interact with the nicotinic acetylcholine receptor.
Mechanism of action[edit | edit source]
Alpha-Bungarotoxin works by binding to the nicotinic acetylcholine receptors at the neuromuscular junction. This prevents the binding of acetylcholine, a neurotransmitter, to these receptors, which in turn inhibits muscle contraction. This can lead to paralysis and potentially death.
Clinical significance[edit | edit source]
Due to its ability to block nicotinic acetylcholine receptors, alpha-bungarotoxin has been used in research to study these receptors. It has also been used in the development of drugs for diseases such as myasthenia gravis and Alzheimer's disease.
See also[edit | edit source]
References[edit | edit source]
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