Alpha-Bungarotoxin

Alpha-Bungarotoxin is a type of neurotoxin that is produced by the many-banded krait snake. It is a member of the three-finger toxin family and is known for its ability to block nicotinic acetylcholine receptors.

Structure[edit | edit source]

Alpha-Bungarotoxin is a protein that consists of 74 amino acid residues. It has a three-finger structure, which is common among snake venom toxins. The three loops extend out from a central core, and the tips of these loops contain the residues that interact with the nicotinic acetylcholine receptor.

Mechanism of action[edit | edit source]

Alpha-Bungarotoxin works by binding to the nicotinic acetylcholine receptors at the neuromuscular junction. This prevents the binding of acetylcholine, a neurotransmitter, to these receptors, which in turn inhibits muscle contraction. This can lead to paralysis and potentially death.

Clinical significance[edit | edit source]

Due to its ability to block nicotinic acetylcholine receptors, alpha-bungarotoxin has been used in research to study these receptors. It has also been used in the development of drugs for diseases such as myasthenia gravis and Alzheimer's disease.

References[edit | edit source]

Alpha-Bungarotoxin Resources
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