Aluminium clofibrate
A chemical compound used in the treatment of hyperlipidemia
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Aluminium clofibrate is a chemical compound used in the treatment of hyperlipidemia, a condition characterized by elevated levels of lipids in the blood. It is a derivative of clofibrate, a fibrate class medication that helps to lower cholesterol and triglyceride levels.
Chemical Structure[edit | edit source]
Aluminium clofibrate is the aluminium salt of clofibrate. The chemical structure consists of clofibrate molecules complexed with aluminium ions. This formulation is designed to enhance the drug's stability and bioavailability.
Mechanism of Action[edit | edit source]
Aluminium clofibrate works by activating peroxisome proliferator-activated receptors (PPARs), specifically PPAR-alpha. Activation of these receptors leads to increased oxidation of fatty acids, decreased production of triglycerides, and increased levels of high-density lipoprotein (HDL) cholesterol. This results in a reduction of low-density lipoprotein (LDL) cholesterol and triglycerides in the bloodstream.
Clinical Use[edit | edit source]
Aluminium clofibrate is primarily used to treat patients with hyperlipidemia, particularly those who have not responded adequately to dietary modifications and other lifestyle changes. It is effective in reducing the risk of atherosclerosis and associated cardiovascular diseases by lowering lipid levels.
Side Effects[edit | edit source]
Common side effects of aluminium clofibrate include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. Long-term use may lead to the development of gallstones due to increased cholesterol excretion in bile. Patients may also experience muscle pain or weakness, a condition known as myopathy, which can progress to rhabdomyolysis in severe cases.
Contraindications[edit | edit source]
Aluminium clofibrate is contraindicated in patients with severe liver or kidney dysfunction, as well as those with pre-existing gallbladder disease. It should be used with caution in patients with a history of peptic ulcer disease or gastrointestinal bleeding.
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