Aluminium clofibrate

Aluminium clofibrate is a chemical compound that belongs to the class of medicinal drugs known as fibrates. It is primarily used in the treatment of hyperlipidemia, a condition characterized by abnormally high levels of lipids in the blood.

Chemical Structure

Aluminium clofibrate is a complex ester of clofibric acid and aluminium hydroxide. The aluminium ion in the compound is coordinated to the carboxylate groups of two clofibric acid molecules, forming a stable complex.

Pharmacology

The primary mechanism of action of aluminium clofibrate involves the activation of peroxisome proliferator-activated receptors (PPARs), specifically PPAR-alpha. This activation leads to an increase in the breakdown of fatty acids and a decrease in the production of triglycerides, thereby lowering the levels of lipids in the blood.

Clinical Use

Aluminium clofibrate is used in the treatment of hyperlipidemia, particularly in cases where diet and lifestyle changes have not been effective. It is also used in the management of coronary artery disease and peripheral vascular disease, as it can help to reduce the risk of atherosclerosis.

Side Effects

Like other fibrates, aluminium clofibrate can cause side effects such as nausea, diarrhea, and abdominal pain. In rare cases, it can also cause more serious side effects such as liver damage and myopathy.

See Also

• Fibrates
• Hyperlipidemia
• Peroxisome proliferator-activated receptors