Amflutizole

Amflutizole is a drug that is used in the treatment of hyperthyroidism. It is a thioamide, a class of drugs that inhibit the production of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This prevents the formation of thyroxine and triiodothyronine, hormones that regulate the body's metabolic rate.

Mechanism of action

Amflutizole works by inhibiting the enzyme thyroid peroxidase, which is involved in the production of thyroid hormones. This results in a decrease in the levels of these hormones, which can help to alleviate the symptoms of hyperthyroidism.

Side effects

Like other thioamides, amflutizole can cause side effects. These can include skin rash, nausea, vomiting, abdominal pain, headache, arthralgia, and myalgia. In rare cases, it can cause agranulocytosis, a serious condition that involves a decrease in the number of white blood cells.

Interactions

Amflutizole can interact with other drugs, including beta blockers, anticoagulants, and digoxin. It can also interact with iodine supplements and foods that are high in iodine.

Contraindications

Amflutizole is contraindicated in patients with liver disease, as it can cause hepatotoxicity. It is also contraindicated in patients with allergies to thioamides.

See also

• Thioamide
• Hyperthyroidism
• Thyroid peroxidase

Amflutizole Resources
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