Amfonelic acid

Amfonelic acid (IUPAC name: 2-(p-Aminobenzoyl)-3-phenylquinoline-4-carboxylic acid) is a stimulant that is known for its psychostimulant properties. It was first synthesized in the 1970s by Sterling Drug, a pharmaceutical company.

Chemistry

Amfonelic acid is a quinoline derivative. It has a phenyl group attached to the 3-position and a carboxylic acid group attached to the 4-position of the quinoline ring. The 2-position of the ring is substituted with a p-aminobenzoyl group.

Pharmacology

Amfonelic acid acts as a potent and selective dopamine reuptake inhibitor, meaning it increases the levels of dopamine in the brain by blocking its reuptake into the presynaptic neuron. This results in increased neurotransmission of dopamine, which is associated with mood elevation and increased alertness.

Effects

The effects of amfonelic acid can include increased energy, enhanced focus, and improved mood. However, it can also cause side effects such as insomnia, increased heart rate, and potential for addiction.

Legal Status

In many countries, amfonelic acid is a controlled substance due to its potential for abuse. However, it is not currently controlled in the United States.

Research

While amfonelic acid has been studied for its potential use in treating attention deficit hyperactivity disorder (ADHD) and narcolepsy, its high potential for abuse and addiction has limited its use in clinical settings.

See Also

• Stimulant
• Dopamine reuptake inhibitor
• Quinoline