Amyloid plaques

Amyloid Plaques are deposits of proteins that accumulate in the brains of patients with Alzheimer's disease. They are a characteristic feature of the disease and are commonly found in the grey matter of the brain.

Overview

Amyloid plaques are primarily composed of beta-amyloid, a sticky protein that clumps together to form plaques. These plaques are believed to disrupt the normal functioning of neurons, leading to the cognitive decline observed in Alzheimer's disease.

Formation

The formation of amyloid plaques is a complex process that involves the cleavage of a larger protein, known as amyloid precursor protein (APP), into smaller beta-amyloid fragments. These fragments then aggregate to form insoluble plaques in the brain.

Role in Alzheimer's Disease

While the exact role of amyloid plaques in Alzheimer's disease is still a topic of ongoing research, it is believed that the accumulation of these plaques leads to the death of neurons and the subsequent cognitive decline observed in the disease.

Treatment

Currently, there is no cure for Alzheimer's disease. However, several treatments are being investigated that aim to reduce the formation of amyloid plaques or to enhance the body's ability to clear these plaques from the brain.

See Also

• Alzheimer's disease
• Beta-amyloid
• Amyloid precursor protein (APP)

Amyloid plaques Resources
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