Androgen synthesis inhibitor
Androgen synthesis inhibitors are a class of drugs, often used in the treatment of diseases such as prostate cancer and hirsutism. These drugs work by inhibiting the production of androgens, which are hormones that play a role in male traits and reproductive activity.
Mechanism of Action[edit | edit source]
Androgen synthesis inhibitors work by blocking the enzymes that are involved in the production of androgens. These enzymes include 17α-hydroxylase and C17,20-lyase, which are critical in the synthesis of androgens in the adrenal glands, testes, and prostate.
Uses[edit | edit source]
Androgen synthesis inhibitors are primarily used in the treatment of prostate cancer. They can also be used to treat conditions such as hirsutism, which is characterized by excessive hair growth in women. In addition, they can be used in the treatment of polycystic ovary syndrome (PCOS), a condition characterized by elevated levels of androgens in women.
Side Effects[edit | edit source]
Like all drugs, androgen synthesis inhibitors can have side effects. These can include fatigue, hot flashes, and sexual dysfunction. In addition, they can cause changes in body composition, such as increased body fat and decreased muscle mass.
Examples[edit | edit source]
Examples of androgen synthesis inhibitors include abiraterone acetate, which is used in the treatment of metastatic castration-resistant prostate cancer, and ketoconazole, which is used off-label in the treatment of prostate cancer.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD