Anecortave
Anecortave is a synthetic derivative of cortisol, a steroid hormone produced by the adrenal glands. It was developed by Alcon Laboratories for the treatment of age-related macular degeneration (AMD) and angiogenesis (the formation of new blood vessels). However, it is not currently approved for use in any country.
Mechanism of Action[edit | edit source]
Anecortave inhibits angiogenesis by suppressing the production of vascular endothelial growth factor (VEGF), a protein that promotes the growth of new blood vessels. This makes it potentially useful in treating conditions like AMD, where abnormal blood vessel growth in the retina can lead to vision loss.
Clinical Trials[edit | edit source]
Several clinical trials have been conducted to evaluate the safety and efficacy of anecortave. In a Phase II trial, anecortave was found to slow the progression of AMD in some patients. However, a subsequent Phase III trial did not meet its primary endpoint, and development of the drug was discontinued.
Side Effects[edit | edit source]
The most common side effects of anecortave include eye pain, cataract formation, and increased intraocular pressure. These side effects are generally mild and resolve on their own after treatment is discontinued.
See Also[edit | edit source]
Anecortave Resources | |
---|---|
|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD