Ankylosing vertebral hyperostosis with tylosis

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Ankylosing vertebral hyperostosis with tylosis
Synonyms	Forestier's disease with tylosis
Pronounce	N/A
Specialty	Rheumatology
Symptoms	Back pain, stiffness, thickened skin on palms and soles
Complications	N/A
Onset	Middle age
Duration	Chronic
Types	N/A
Causes	Genetic mutation
Risks	Family history
Diagnosis	X-ray, CT scan, MRI
Differential diagnosis	Ankylosing spondylitis, Diffuse idiopathic skeletal hyperostosis
Prevention	N/A
Treatment	Physical therapy, pain management, surgery
Medication	NSAIDs, analgesics
Prognosis	Variable, depends on severity
Frequency	Rare
Deaths	N/A

Alternate names

Familial ankylosing vertebral hyperostosis with tylosis

Definition

A rare dysostosis with predominant vertebral involvement characterized by paraspinal ligament ossification (most pronounced in the lower thoracic region), osteophytosis, marginal sacroiliac joint sclerosis, and punctate hyperkeratosis on the soles and palms. Patients may be asymptomatic or present mild to moderate back pain. There have been no further descriptions in the literature since 1969.

NIH genetic and rare disease info

• NIH info on Ankylosing vertebral hyperostosis with tylosis

Ankylosing vertebral hyperostosis with tylosis is a rare disease.

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