Anti-cardiolipin

Anti-cardiolipin (antibodies) are autoantibodies, often present in autoimmune diseases such as systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). They are directed against a protein-binding complex in the body, specifically cardiolipin, a phospholipid that plays a key role in the coagulation pathway.

Overview

Anti-cardiolipin antibodies are a type of autoantibody, a group of antibodies that the body mistakenly produces against its own tissues. They are directed against cardiolipin, a phospholipid molecule that is found in the inner mitochondrial membrane of cells, and is also a component of the coagulation (blood clotting) pathway.

Clinical significance

The presence of anti-cardiolipin antibodies can lead to a number of clinical conditions, most notably antiphospholipid syndrome (APS). APS is an autoimmune disorder characterized by recurrent venous or arterial thrombosis (blood clots) and/or pregnancy-related complications such as miscarriage, stillbirth, preterm delivery, or severe preeclampsia.

In addition to APS, anti-cardiolipin antibodies are also commonly found in individuals with systemic lupus erythematosus (SLE), a chronic autoimmune disease that can affect various parts of the body, including the skin, joints, kidneys, and nervous system.

Testing

Testing for anti-cardiolipin antibodies is typically done through a blood test. This test is often performed on individuals who have had unexplained blood clots or recurrent pregnancy loss, as these are common symptoms of conditions associated with anti-cardiolipin antibodies.

Treatment

Treatment for conditions associated with anti-cardiolipin antibodies typically involves managing the symptoms and preventing complications. This may include the use of medications to prevent blood clots, such as aspirin or anticoagulants.

See also

• Antiphospholipid syndrome
• Systemic lupus erythematosus
• Autoantibody
• Cardiolipin

Anti-cardiolipin Resources
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