Anti-lymphocyte globulin

Anti-lymphocyte globulin (ALG) is a type of immunotherapy that is used to suppress the immune system. It is made from the serum of animals that have been immunized against human lymphocytes. ALG is used in the treatment of various autoimmune diseases, organ transplant rejection, and certain blood disorders.

Uses

ALG is primarily used in the treatment of acute rejection in organ transplant patients. It is also used in the treatment of certain autoimmune diseases and blood disorders, such as aplastic anemia and leukemia.

Mechanism of Action

ALG works by binding to the surface of lymphocytes, a type of white blood cell, and inhibiting their function. This suppresses the immune response and prevents the body from attacking its own cells or rejecting a transplanted organ.

Side Effects

Common side effects of ALG include fever, chills, rash, and nausea. More serious side effects can include anaphylaxis, a severe allergic reaction, and serum sickness, a reaction to the animal proteins in the drug.

Contraindications

ALG should not be used in patients with a known allergy to the drug or any of its components. It should also be used with caution in patients with a history of anaphylaxis or serum sickness.

See Also

• Immunosuppressive drugs
• Organ transplantation
• Autoimmune diseases
• Blood disorders