Archival research

From WikiMD.com Medical Encyclopedia

A nonsteroidal anti-inflammatory drug


Archival research
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number 54300-20-8
PubChem 68770
DrugBank
ChemSpider 62020
KEGG D02899


Antrafenine is a nonsteroidal anti-inflammatory drug (NSAID) that was developed for the treatment of pain and inflammation. It is part of a class of drugs that work by inhibiting the production of prostaglandins, which are compounds involved in the inflammatory response.

Pharmacology[edit | edit source]

Antrafenine functions by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes are responsible for the conversion of arachidonic acid to prostaglandins, which mediate inflammation, pain, and fever. By blocking these enzymes, antrafenine reduces the synthesis of prostaglandins, thereby alleviating symptoms associated with inflammation.

Clinical Use[edit | edit source]

Antrafenine is used primarily for its analgesic and anti-inflammatory properties. It is indicated for the treatment of conditions such as arthritis, musculoskeletal pain, and other inflammatory disorders. The drug is administered orally and is absorbed through the gastrointestinal tract.

Side Effects[edit | edit source]

As with other NSAIDs, antrafenine can cause a range of side effects. Common adverse effects include gastrointestinal discomfort, such as nausea, vomiting, and gastric ulceration. Long-term use may increase the risk of cardiovascular events and renal impairment. Patients are advised to use the lowest effective dose for the shortest duration necessary to minimize these risks.

Synthesis[edit | edit source]

The synthesis of antrafenine involves the chemical modification of a phenylpropionic acid derivative. The process includes the introduction of a chloro group to the aromatic ring, followed by the formation of the propanoic acid moiety. The detailed synthetic pathway is illustrated in the accompanying diagram.

Related pages[edit | edit source]

Gallery[edit | edit source]

  • Chemical structure of Antrafenine

  • Synthesis pathway of Antrafenine

  • Secretary hand bond from 1623

  • Hoover Archive Reading Room

  • Research Center Photo by Kirsten

  • Reading hall of the Norwegian National Archive

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Retrieved from "https://wikimd.com/w/index.php?title=Archival_research&oldid=6316781"

Contributors: Prab R. Tumpati, MD