Asp homolog

The Asp homolog (ASPH) is a protein encoded by the ASPH gene in humans. It is a member of the aspartyl/asparaginyl β-hydroxylase family and plays a crucial role in the post-translational modification of proteins.

Structure

The ASPH protein is composed of several domains, including an N-terminal signal peptide, a jelly-roll fold domain, and a C-terminal catalytic domain. The catalytic domain is responsible for the hydroxylation of aspartyl and asparaginyl residues in target proteins. The structure of ASPH allows it to interact with various substrates and cofactors, facilitating its enzymatic activity.

Function

ASPH is primarily involved in the post-translational modification of proteins through the hydroxylation of aspartyl and asparaginyl residues. This modification is critical for the proper folding and function of many proteins. ASPH is also implicated in calcium homeostasis and cell signaling pathways. It is expressed in various tissues, including the liver, heart, and brain.

Role in Development

During embryonic development, ASPH is highly expressed and is thought to play a role in the differentiation and proliferation of cells. It is particularly important in the development of the nervous system and cardiovascular system.

Role in Disease

Mutations or dysregulation of the ASPH gene have been associated with several diseases. Overexpression of ASPH has been observed in various cancers, including hepatocellular carcinoma and breast cancer. It is thought to contribute to tumor progression and metastasis by promoting cell proliferation and inhibiting apoptosis.

Clinical Significance

ASPH is a potential target for therapeutic intervention in cancer treatment. Inhibitors of ASPH activity are being investigated for their ability to suppress tumor growth and metastasis. Additionally, ASPH may serve as a biomarker for certain types of cancer, aiding in diagnosis and prognosis.

Research Directions

Current research on ASPH focuses on understanding its precise role in normal physiology and disease. Studies are exploring the molecular mechanisms by which ASPH contributes to cancer progression and its potential as a therapeutic target. There is also interest in the development of specific inhibitors that can modulate ASPH activity in pathological conditions.

See Also

• Post-translational modification
• Protein hydroxylation
• Oncogene

External Links

• [UniProt entry for ASPH](https://www.uniprot.org/uniprot/Q12797)
• [GeneCards entry for ASPH](https://www.genecards.org/cgi-bin/carddisp.pl?gene=ASPH)

This article is a stub related to proteins. You can help WikiMD by expanding it!