Augusto, Michaela, and Lorenzo Odone

Augusto, Michaela, and Lorenzo Odone
Known for	Development of Lorenzo's Oil

Augusto, Michaela, and Lorenzo Odone are known for their pioneering work in the development of Lorenzo's Oil, a treatment for adrenoleukodystrophy (ALD), a rare genetic disorder. Their story gained international attention and was the subject of the 1992 film Lorenzo's Oil.

Background

Adrenoleukodystrophy is a genetic disorder that affects the nervous system and the adrenal glands. It is caused by a mutation in the ABCD1 gene, which leads to the accumulation of very long-chain fatty acids (VLCFAs) in the body. This accumulation damages the myelin sheath, which insulates nerve cells, leading to neurological deterioration.

The Odone Family

Augusto Odone, an economist, and Michaela Odone, a linguist, were the parents of Lorenzo Odone, who was diagnosed with ALD at the age of five. Faced with the grim prognosis and the lack of effective treatments, the Odones embarked on a quest to find a solution for their son's condition.

Development of Lorenzo's Oil

The Odones, despite having no formal medical training, immersed themselves in scientific research. They collaborated with scientists and researchers to develop a treatment that could potentially halt the progression of ALD. Their efforts led to the creation of Lorenzo's Oil, a mixture of oleic acid and erucic acid, which was shown to reduce the levels of VLCFAs in the body.

Impact and Legacy

Lorenzo's Oil has been used as a treatment for ALD, particularly in asymptomatic boys who are at risk of developing the disease. The Odones' work has inspired further research into ALD and other similar disorders. Their story highlights the impact of patient advocacy and the potential for non-scientists to contribute to medical research.

Also see

• Adrenoleukodystrophy
• Lorenzo's Oil (film)
• Genetic disorders
• Patient advocacy