BCX4430
BCX4430 is an experimental antiviral drug developed by BioCryst Pharmaceuticals. It is a nucleoside analog which disrupts the process of viral replication, and it has been investigated for possible use against a number of RNA viruses.
Mechanism of action[edit | edit source]
BCX4430 is a broad-spectrum nucleoside analog which inhibits the RNA-dependent RNA polymerase (RdRp) of various RNA viruses. This enzyme is essential for the replication of the viral genome, and by inhibiting it, BCX4430 prevents the virus from multiplying within the host cell.
Development and testing[edit | edit source]
BCX4430 was developed by BioCryst Pharmaceuticals, a company based in Durham, North Carolina. It was initially investigated for its potential use against hepatitis C, but was later found to have activity against a wider range of viruses.
In 2014, the drug was tested in a non-human primate model of Marburg virus disease, with promising results. It was also found to be effective in vitro against a number of other viruses, including Ebola virus, Hendra virus, and Nipah virus.
In 2015, BioCryst received funding from the National Institute of Allergy and Infectious Diseases (NIAID) to further develop BCX4430 as a treatment for Ebola virus disease.
Clinical trials[edit | edit source]
In 2016, a phase 1 clinical trial of BCX4430 was initiated. This trial aimed to assess the safety, tolerability, and pharmacokinetics of the drug in healthy volunteers.
See also[edit | edit source]
- Antiviral drug
- Nucleoside analog
- RNA-dependent RNA polymerase
- Marburg virus disease
- Ebola virus disease
- Hendra virus
- Nipah virus
| BCX4430 Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
