BD-1067

BD-1067 is a sigma receptor antagonist, with a greater affinity for the sigma-1 subtype, but still potent at the sigma-2 subtype. It has neuroprotective effects and has been investigated for the treatment of schizophrenia.

Pharmacology[edit | edit source]

BD-1067 is a potent and selective sigma receptor antagonist. It has a higher affinity for the sigma-1 receptor subtype, but is still potent at the sigma-2 receptor subtype. The sigma receptors are a set of proteins located in the membrane of certain neurons. They are thought to have a role in several diseases, including schizophrenia, depression, and drug addiction.

BD-1067 has been shown to have neuroprotective effects. It can protect neurons from damage caused by excitotoxicity, a process that is thought to be involved in several neurological diseases, including Alzheimer's disease and Parkinson's disease.

Clinical significance[edit | edit source]

BD-1067 has been investigated for the treatment of schizophrenia. Schizophrenia is a chronic and severe mental disorder that affects how a person thinks, feels, and behaves. It is thought to be caused by a combination of genetic and environmental factors, and is associated with changes in brain chemistry and structure.

BD-1067 has been shown to reduce the psychotic symptoms of schizophrenia in animal models. It is thought to work by blocking the action of dopamine, a neurotransmitter that is thought to be overactive in the brains of people with schizophrenia.

References[edit | edit source]

BD-1067 Resources
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