BMS-180,291
BMS-180,291
BMS-180,291 is a chemical compound that has been studied for its potential pharmacological effects. It is primarily known for its role as a selective antagonist of the 5-HT1D serotonin receptor, which is implicated in various neurological processes.
Chemical Structure and Properties[edit | edit source]
BMS-180,291 is a synthetic compound with a complex molecular structure. The chemical formula is C19H22N2O2, and it has a molecular weight of 310.39 g/mol. The compound is characterized by its specific binding affinity to the 5-HT1D receptor, which is a subtype of the serotonin receptor family.
Pharmacology[edit | edit source]
BMS-180,291 acts as a selective antagonist at the 5-HT1D receptor. This receptor is part of the larger family of 5-HT receptors, which are G protein-coupled receptors (GPCRs) involved in the modulation of neurotransmission. The 5-HT1D receptor is primarily found in the central nervous system and is thought to play a role in the regulation of mood, anxiety, and migraine pathophysiology.
Mechanism of Action[edit | edit source]
As an antagonist, BMS-180,291 binds to the 5-HT1D receptor and inhibits its activation by endogenous serotonin. This blockade can alter the downstream signaling pathways that are normally activated by serotonin binding, potentially leading to changes in neurotransmitter release and neuronal excitability.
Therapeutic Potential[edit | edit source]
The selective antagonism of the 5-HT1D receptor by BMS-180,291 has been explored for its potential therapeutic applications, particularly in the treatment of migraine headaches. By inhibiting the 5-HT1D receptor, BMS-180,291 may reduce the vasoconstriction and neurogenic inflammation associated with migraine attacks.
Research and Development[edit | edit source]
BMS-180,291 was developed and studied by Bristol-Myers Squibb as part of their research into novel treatments for neurological disorders. While it showed promise in preclinical studies, further clinical trials are necessary to fully understand its efficacy and safety profile in humans.
Safety and Side Effects[edit | edit source]
As with any pharmacological agent, the safety and side effect profile of BMS-180,291 must be thoroughly evaluated. Potential side effects could include alterations in mood, dizziness, or gastrointestinal disturbances, which are common with drugs affecting the serotonin system.
Also see[edit | edit source]
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