BMS 470539

BMS 470539

BMS 470539 is a chemical compound that acts as a selective agonist for the calcium sensing receptor (CaSR). It is primarily used in scientific research to explore the role of the CaSR in various biological systems.

Chemistry

BMS 470539 is a synthetic compound with a complex molecular structure. It is a derivative of phenylalanine, one of the essential amino acids. The compound's full chemical name is N-[(1R)-1-(3-bromophenyl)ethyl]-1,1-difluoro-2-(1H-indol-3-yl)ethanamine.

Pharmacology

BMS 470539 acts as a potent and selective agonist for the calcium sensing receptor (CaSR). The CaSR is a G protein-coupled receptor that plays a crucial role in regulating the body's calcium homeostasis. By activating the CaSR, BMS 470539 can influence a variety of biological processes, including cell proliferation, differentiation, and apoptosis.

Research Applications

BMS 470539 has been used in a variety of research contexts to study the role of the CaSR in different biological systems. For example, it has been used to investigate the CaSR's role in bone metabolism, cardiovascular function, and kidney function. It has also been used to explore potential therapeutic applications for CaSR agonists in conditions such as osteoporosis, hypoparathyroidism, and kidney disease.

Safety and Toxicity

As a research chemical, BMS 470539 is not intended for human consumption. Its safety and toxicity in humans have not been thoroughly studied. However, in animal studies, it has been shown to have a relatively low toxicity profile.

See Also

• Calcium sensing receptor
• G protein-coupled receptor
• Phenylalanine