BTRX-335140
BTRX-335140 (also known as BTRX-140, KOR antagonist 2, or Compound 2) is a novel, orally available, and selective kappa opioid receptor (KOR) antagonist that is being developed by BlackThorn Therapeutics for the treatment of neurobehavioral disorders.
Chemistry[edit | edit source]
BTRX-335140 is a small molecule that selectively antagonizes the kappa opioid receptor. It is structurally distinct from other known KOR antagonists. The chemical structure of BTRX-335140 is represented by the following chemical formula: C22H23N5O.
Pharmacology[edit | edit source]
BTRX-335140 acts as an antagonist at the kappa opioid receptor, a type of G protein-coupled receptor (GPCR) that is activated by the endogenous opioid dynorphin. By blocking the activity of dynorphin at the KOR, BTRX-335140 is thought to alleviate symptoms associated with neurobehavioral disorders.
Clinical Development[edit | edit source]
BTRX-335140 is currently in clinical development for the treatment of neurobehavioral disorders. In preclinical studies, BTRX-335140 demonstrated a favorable safety profile and efficacy in models of depression and anxiety. The drug is currently being evaluated in Phase 2 clinical trials.
Potential Therapeutic Applications[edit | edit source]
The kappa opioid receptor has been implicated in a variety of neurobehavioral disorders, including depression, anxiety disorders, and substance use disorders. By antagonizing the KOR, BTRX-335140 may have therapeutic potential in these conditions.
See Also[edit | edit source]
References[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
