Baboon syndrome

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Baboon syndrome
Synonyms Systemic contact dermatitis, symmetrical drug-related intertriginous and flexural exanthema (SDRIFE)
Pronounce N/A
Specialty N/A
Symptoms Rash, erythema, pruritus
Complications Secondary infection
Onset Hours to days after exposure
Duration Variable, depending on exposure
Types N/A
Causes Drug reaction, contact dermatitis
Risks Previous exposure to causative agent
Diagnosis Clinical evaluation, patch test
Differential diagnosis Fixed drug eruption, toxic epidermal necrolysis, Stevens-Johnson syndrome
Prevention Avoidance of known triggers
Treatment Corticosteroids, antihistamines
Medication N/A
Prognosis Generally good with avoidance of trigger
Frequency Rare
Deaths N/A


Baboon Syndrome is a distinctive skin condition characterized by a bright red rash on the buttocks and inner thighs, resembling the red bottom of a baboon. It is also known as Systemic Contact Dermatitis (SCD) and is often caused by exposure to certain medications or substances.

Causes[edit | edit source]

Baboon Syndrome is usually triggered by exposure to certain substances, including medications such as antibiotics, antifungals, and even some herbal supplements. It can also be caused by exposure to heavy metals like mercury or nickel. Allergic reactions to these substances can lead to the development of the syndrome.

Symptoms[edit | edit source]

The primary symptom of Baboon Syndrome is a bright red rash that appears on the buttocks and inner thighs. The rash may also spread to other parts of the body. Other symptoms can include itching, burning, and discomfort in the affected areas.

Diagnosis[edit | edit source]

Diagnosis of Baboon Syndrome is primarily based on the characteristic appearance of the rash. A dermatologist may also perform a patch test to identify the substance causing the allergic reaction.

Treatment[edit | edit source]

Treatment for Baboon Syndrome primarily involves avoiding the substance that caused the allergic reaction. Topical corticosteroids and antihistamines may also be used to help manage symptoms. In severe cases, systemic corticosteroids may be required.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD