Baculoviral IAP repeat-containing protein 2

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Protein BIRC2 PDB 1qbh

Baculoviral IAP repeat-containing protein 2

Baculoviral IAP repeat-containing protein 2 (BIRC2), also known as cIAP1, is a protein that in humans is encoded by the BIRC2 gene. BIRC2 is a member of the inhibitor of apoptosis (IAP) gene family. This protein contains three baculovirus IAP repeats and a RING finger domain. It has been shown to interact with tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, and thus plays a role in the signal transduction pathway leading to apoptosis.

Structure[edit | edit source]

BIRC2 contains three baculovirus IAP repeats (BIR) and a RING finger domain. The BIR domains are responsible for protein-protein interactions, particularly with TRAF1 and TRAF2. The RING finger domain is involved in E3 ubiquitin ligase activity, which allows BIRC2 to ubiquitinate target proteins for degradation.

Function[edit | edit source]

BIRC2 functions as an inhibitor of apoptosis by inhibiting caspases, which are key enzymes in the apoptotic pathway. It also plays a role in regulating immune responses and inflammation through its interactions with TRAF1 and TRAF2.

Clinical significance[edit | edit source]

Mutations in the BIRC2 gene have been associated with autoimmune diseases and cancer. Dysregulation of BIRC2 expression can lead to abnormal cell survival and proliferation, contributing to disease pathogenesis.

Interactions[edit | edit source]

BIRC2 interacts with various proteins involved in the apoptotic and inflammatory pathways, including TRAF1, TRAF2, and caspases. These interactions modulate cell signaling processes and determine cell fate.

References[edit | edit source]

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Contributors: Prab R. Tumpati, MD