Basigin
Basigin is a protein that in humans is encoded by the BSG gene. It is also known as CD147, EMMPRIN (extracellular matrix metalloproteinase inducer), or TCSF (tumor cell-derived collagenase-stimulatory factor).
Function[edit | edit source]
Basigin is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta chain. This protein plays a role in the development, physiology, and pathology of the nervous system and in the immune response. Basigin is a glycoprotein with different forms resulting from different modes of transcription.
Clinical significance[edit | edit source]
Basigin has been shown to stimulate the production and release of matrix metalloproteinase (MMP) in neighboring fibroblasts and it is used by many cancer cells to induce the production of these enzymes and degrade the extracellular matrix to facilitate invasion and metastasis. It is overexpressed in many tumor types and is associated with poor prognosis.
Interactions[edit | edit source]
Basigin has been shown to interact with Caveolin 1 and Glycoprotein M6A.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- Basigin at the US National Library of Medicine Medical Subject Headings (MeSH)
| Basigin Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
