BeKm-1 toxin

BeKm-1 toxin is a peptide toxin derived from the venom of the Central Asian scorpion Buthus eupeus. It is a potent and selective blocker of the human ether-à-go-go-related gene (hERG) potassium channel, which plays a crucial role in the cardiac action potential and is involved in various cardiac disorders.

Structure

BeKm-1 is a small peptide consisting of 36 amino acid residues. It is cross-linked by three disulfide bonds, which contribute to its compact, stable structure. The toxin's structure is characterized by a core of alpha-helical and beta sheet regions, surrounded by flexible loops.

Mode of Action

BeKm-1 selectively binds to the hERG channel, blocking its function. This blockage inhibits the flow of potassium ions through the channel, which can disrupt the normal rhythm of the heart. The exact binding site and mechanism of action of BeKm-1 are still under investigation.

Clinical Significance

Due to its potent and selective action on the hERG channel, BeKm-1 has potential therapeutic applications. It could be used as a tool for studying the hERG channel and its role in cardiac function and disease. Furthermore, it could serve as a lead compound for the development of new drugs for the treatment of cardiac arrhythmias.

See Also

• Scorpion venom
• Ion channel
• Cardiac arrhythmia