Benzestrol

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Benzestrol

Benzestrol is a synthetic, nonsteroidal estrogen of the stilbestrol group that is related to diethylstilbestrol and used in the treatment of menopausal and postmenopausal disorders. It is no longer in widespread use.

History

Benzestrol was first synthesized in the 1930s as part of a large series of related compounds, the stilbestrols, which were produced in response to the need for a more potent estrogenic substance. It was one of the first nonsteroidal estrogens to be synthesized.

Pharmacology

Benzestrol, like other synthetic estrogens, binds to the estrogen receptor and mimics the action of natural estrogens in the body. It is a potent estrogen, and has been used in the treatment of menopausal symptoms, such as hot flashes and vaginal dryness. However, due to its potency and the risk of serious side effects, it is no longer widely used.

Side Effects

The side effects of benzestrol are similar to those of other potent synthetic estrogens. These can include nausea, vomiting, bloating, abdominal cramps, headache, and weight gain. More serious side effects can include an increased risk of blood clots, stroke, and certain types of cancer.

Legal Status

In the United States, benzestrol is no longer marketed. It was withdrawn from the market due to concerns about its safety, particularly the risk of serious side effects such as blood clots and cancer.

See Also

• Diethylstilbestrol
• Estrogen
• Estrogen receptor
• Menopause
• Postmenopause