Beta-Hydroxy beta-methylbutyric acid

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β-Hydroxy β-methylbutyric acid (HMB)[edit | edit source]

Overview[edit | edit source]

Infographic illustrating the chemical structure of β-Hydroxy β-methylbutyric acid (HMB).

β-Hydroxy β-methylbutyric acid (HMB), also known as its conjugate base, β-hydroxy β-methylbutyrate, is a naturally produced substance in humans. It plays a significant role in muscle health and is used both as a dietary supplement and as an ingredient in certain medical foods.

Role in the Body[edit | edit source]

HMB is involved in the synthesis of muscle tissue and has been shown to reduce muscle breakdown. It is a metabolite of the essential amino acid Leucine, which is known for its role in protein synthesis and muscle repair.

Medical and Dietary Uses[edit | edit source]

HMB supplements in capsule form.

HMB supplements are used to promote wound healing and provide nutritional support for people with muscle wasting due to conditions like Cancer or HIV/AIDS. It is particularly beneficial for preserving muscle mass in individuals who are immobilized or undergoing periods of muscle disuse.

Benefits in Exercise and Recovery[edit | edit source]

In healthy adults, supplementation with HMB has been shown to:

  • Increase exercise-induced gains in muscle size, muscle strength, and lean body mass.
  • Reduce skeletal muscle damage from exercise.
  • Improve aerobic exercise performance.
  • Expedite recovery from exercise.

Research and Reviews[edit | edit source]

Medical reviews and meta-analyses indicate that HMB supplementation helps to preserve or increase lean body mass and muscle strength in individuals experiencing age-related muscle loss or other conditions leading to muscle atrophy.

Safety and Dosage[edit | edit source]

The safety profile of HMB supplementation is generally considered good, but as with any supplement, it should be used under the guidance of a healthcare professional.

References[edit | edit source]


Resources[edit source]

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Beta-Hydroxy beta-methylbutyric acid for any updates.


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