Bidomain model

Bidomain Model is a mathematical model used in biophysics and computational biology to simulate the electrical properties of cardiac tissue. The model represents the cardiac tissue as two continuous, overlapping domains (the intra- and extracellular spaces), each with its own electrical conductivity.

Overview

The Bidomain Model is a representation of the electrical properties of cardiac tissue. It is used to simulate the propagation of electrical signals in the heart, which is crucial for understanding the mechanisms of cardiac arrhythmias and for developing treatments for these conditions.

The model represents the cardiac tissue as two continuous, overlapping domains: the intracellular space (inside the heart cells) and the extracellular space (outside the heart cells). Each of these domains has its own electrical conductivity, which is determined by the properties of the tissue and the ionic concentration in the respective spaces.

Mathematical Formulation

The Bidomain Model is mathematically formulated as a system of partial differential equations. These equations describe the propagation of electrical signals in the intra- and extracellular spaces, taking into account the electrical conductivity of the tissue and the ionic concentration in the respective spaces.

The model also includes a term for the membrane potential, which represents the difference in electrical potential between the inside and outside of the heart cells. This potential is crucial for the generation and propagation of electrical signals in the heart.

Applications

The Bidomain Model is widely used in biophysics and computational biology to simulate the electrical properties of cardiac tissue. It is a crucial tool for understanding the mechanisms of cardiac arrhythmias and for developing treatments for these conditions.

The model is also used in the development of cardiac defibrillators and pacemakers, as it allows for the simulation of the effects of these devices on the electrical properties of the heart.

See Also

• Monodomain Model
• Cardiac Electrophysiology
• Computational Biology
• Biophysics

References

Bidomain model Resources
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