Binaltorphimine

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Binaltorphimine (also known as BNI) is a potent and selective antagonist for the kappa opioid receptor. It was originally derived from the opioid alkaloid nor-binaltorphimine. Binaltorphimine has been shown to produce antidepressant-like effects in animal studies.

Chemistry[edit | edit source]

Binaltorphimine is a derivative of the opioid alkaloid nor-binaltorphimine. It is a potent and selective antagonist for the kappa opioid receptor, with a high affinity for this receptor subtype. The chemical structure of binaltorphimine is characterized by a bis-quaternary structure, which is believed to contribute to its high potency and selectivity.

Pharmacology[edit | edit source]

Binaltorphimine acts as an antagonist at the kappa opioid receptor, meaning it blocks the action of kappa opioid agonists. It has a high affinity for the kappa opioid receptor, and a much lower affinity for the mu and delta opioid receptors. This selectivity makes binaltorphimine a useful tool in the study of the kappa opioid system.

Clinical significance[edit | edit source]

The kappa opioid system has been implicated in a number of physiological and pathological processes, including pain, mood disorders, and addiction. Binaltorphimine, as a kappa opioid antagonist, has potential therapeutic applications in these areas. In animal studies, binaltorphimine has been shown to produce antidepressant-like effects, suggesting a potential role in the treatment of depression.

See also[edit | edit source]

References[edit | edit source]


Binaltorphimine Resources

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Contributors: Prab R. Tumpati, MD