Brooke–Fordyce syndrome

Brooke–Fordyce syndrome is a rare condition characterized by multiple, painful, sweat gland tumors. These tumors, also known as apocrine hidrocystomas, typically develop in areas where apocrine sweat glands are found, such as the armpits, groin, and anal region. The condition is named after the two physicians who first described it, Dr. Henry Ambrose Grundy Brooke and Dr. William G. Fordyce.

Symptoms

The primary symptom of Brooke–Fordyce syndrome is the development of multiple, painful, sweat gland tumors. These tumors are typically small, ranging in size from a few millimeters to a few centimeters in diameter. They are often filled with a clear or yellowish fluid. The tumors can cause significant discomfort and may interfere with normal activities.

Causes

The exact cause of Brooke–Fordyce syndrome is unknown. However, it is believed to be related to an abnormality in the apocrine sweat glands. These glands are responsible for producing sweat in certain areas of the body, including the armpits, groin, and anal region. In individuals with Brooke–Fordyce syndrome, these glands appear to overproduce sweat, leading to the formation of tumors.

Diagnosis

Diagnosis of Brooke–Fordyce syndrome is typically made based on the characteristic symptoms and a physical examination. In some cases, a biopsy of the tumor may be performed to confirm the diagnosis.

Treatment

Treatment for Brooke–Fordyce syndrome typically involves surgical removal of the tumors. In some cases, other treatments such as laser therapy or cryotherapy may be used. However, these treatments are not always effective and the tumors often recur.

Prognosis

The prognosis for individuals with Brooke–Fordyce syndrome is generally good. Although the condition can cause significant discomfort, it does not typically affect overall health or lifespan. However, the recurrent nature of the tumors can be frustrating for individuals with the condition.

See also

• Apocrine sweat gland
• Hidrocystoma
• Sweat gland tumor

Brooke–Fordyce syndrome Resources
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