Bufadienolide

Bufadienolide is a type of steroid that is often found in the skin and parotid venom glands of some toad species. It is also present in a variety of plants. Bufadienolides have a similar structure to cardiac glycosides and have been used in traditional medicine for their cardiotonic properties. They have also been investigated for their potential anti-cancer effects.

Chemical Structure

Bufadienolides are a type of cardenolide, a class of steroids that have a 5-membered lactone ring at the C17 position. They are distinguished from other cardenolides by the presence of a double bond between C-1 and C-2 in the steroid nucleus.

Sources

Bufadienolides are found in certain species of toads, particularly those in the genus Bufo. They are also present in a variety of plants, including Digitalis (foxgloves), Helleborus (hellebores), and Strophanthus. Some species of insects, such as the monarch butterfly, are able to sequester bufadienolides from the plants they eat and use them as a defense mechanism against predators.

Medical Uses

Bufadienolides have been used in traditional medicine for their cardiotonic properties. They work by inhibiting the Na+/K+-ATPase pump, which increases the concentration of intracellular calcium and strengthens heart muscle contractions. This makes them useful in the treatment of certain heart conditions, such as congestive heart failure and atrial fibrillation.

In addition to their cardiotonic effects, bufadienolides have also been investigated for their potential anti-cancer properties. Some studies have found that they can induce apoptosis in cancer cells and inhibit tumor growth.

Safety

While bufadienolides can have beneficial effects, they can also be toxic if consumed in large amounts. Symptoms of bufadienolide poisoning can include nausea, vomiting, abdominal pain, and cardiac arrhythmias. In severe cases, it can lead to death.

See Also

• Cardiac glycoside
• Digitalis
• Na+/K+-ATPase

Bufadienolide Resources
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