Buprenorphine/naltrexone

Buprenorphine/naltrexone is a combination drug therapy used in the treatment of opioid dependence. It combines buprenorphine, a partial opioid agonist, and naltrexone, an opioid antagonist, to reduce the risk of opioid overdose and improve treatment outcomes.

Mechanism of Action

Buprenorphine/naltrexone works by combining the effects of buprenorphine and naltrexone. Buprenorphine is a partial opioid agonist, meaning it binds to the same receptors in the brain as opioids but produces a lesser effect. This can help to reduce cravings and withdrawal symptoms in individuals who are dependent on opioids.

Naltrexone, on the other hand, is an opioid antagonist. It works by blocking the effects of opioids on the brain. This can help to prevent the euphoric effects of opioid use and reduce the risk of overdose.

Uses

Buprenorphine/naltrexone is primarily used in the treatment of opioid dependence. It can be used as part of a comprehensive treatment program that includes counseling and psychosocial support.

Side Effects

Like all medications, buprenorphine/naltrexone can cause side effects. These may include nausea, vomiting, headache, dizziness, and sleep problems. In rare cases, serious side effects such as severe withdrawal symptoms and opioid overdose can occur.

See Also

• Opioid dependence
• Buprenorphine
• Naltrexone

References

Buprenorphine/naltrexone Resources
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