Melperone

Melperone is an atypical antipsychotic and sedative that is used in the treatment of schizophrenia and other psychotic disorders. It is also used as a sleep aid due to its sedative properties. Melperone is marketed under the brand name Buronil.

Etymology

The term "Melperone" is derived from the chemical name of the drug, which is 4'-((2-methyl-1-propyl)-3-piperidyl)-2-benzyl-1,1-diphenylbutylone.

Pharmacology

Melperone acts as an antagonist at various dopamine, serotonin, and adrenergic receptors. It has a high affinity for the D2, 5-HT2A, 5-HT2C, and α1-adrenergic receptors, and a moderate affinity for the D1, D3, D4, 5-HT1A, 5-HT6, and α2-adrenergic receptors.

Medical uses

Melperone is used in the treatment of various psychiatric disorders including schizophrenia, acute and chronic psychosis, and agitated states. It is also used as a sleep aid due to its sedative properties.

Side effects

Common side effects of Melperone include drowsiness, dizziness, dry mouth, and weight gain. Less common side effects include extrapyramidal symptoms, tardive dyskinesia, and neuroleptic malignant syndrome.

History

Melperone was first synthesized in the 1960s by the German pharmaceutical company Hoechst AG. It was first marketed in Europe in the 1970s under the brand name Buronil.

See also

• Atypical antipsychotic
• Sedative
• Schizophrenia
• Psychotic disorders

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