CARD

CARD or Caspase Activation and Recruitment Domain is a protein interaction domain that is found in a wide array of proteins, some of which are involved in apoptosis and inflammation processes.

Structure

The CARD domain is a protein module that consists of six alpha-helices. It is found in many proteins that are involved in apoptosis or inflammation. The CARD domain is similar in structure to the death domain (DD), death effector domain (DED), and pyrin domain (PYD), all of which are involved in the formation of death-inducing signaling complexes (DISCs).

Function

The CARD domain is involved in the formation of death-inducing signaling complexes (DISCs), which play a crucial role in apoptosis and inflammation. Proteins with CARD domains can interact with each other, leading to the activation of caspases, enzymes that play a key role in apoptosis.

Proteins with CARD domains

There are many proteins that contain CARD domains. Some of these include:

• Apaf-1
• Caspases
• Bcl-10
• NOD-like receptors
• RIG-I-like receptors

See also

• Apoptosis
• Inflammation
• Caspase
• Protein domain

References

CARD Resources
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