CCDC82

CCDC82

CCDC82 (Coiled-Coil Domain Containing 82) is a protein-coding gene in humans. The gene is located on chromosome 13 and is involved in various cellular processes. The protein encoded by CCDC82 contains a coiled-coil domain, which is a structural motif involved in protein-protein interactions.

Gene Structure

The CCDC82 gene is located on the long arm of chromosome 13 at position 13q14.11. It spans approximately 20 kilobases and consists of multiple exons. The gene is transcribed into mRNA, which is then translated into the CCDC82 protein.

Protein Structure

The CCDC82 protein is characterized by the presence of a coiled-coil domain, which is a common structural motif in proteins that facilitates the formation of protein complexes. Coiled-coil domains are typically involved in the assembly of protein oligomers and are important for the structural integrity and function of the protein.

Function

The exact biological function of CCDC82 is not fully understood. However, proteins with coiled-coil domains are often involved in a variety of cellular processes, including cytoskeleton organization, signal transduction, and transcriptional regulation. CCDC82 may play a role in these processes through its ability to interact with other proteins.

Clinical Significance

Research on CCDC82 is ongoing, and its role in human health and disease is still being elucidated. Variations in the CCDC82 gene may be associated with certain medical conditions, although specific diseases directly linked to CCDC82 have not been conclusively identified. Further studies are needed to determine the clinical significance of CCDC82 and its potential as a biomarker or therapeutic target.

Research and Studies

Several studies have investigated the expression patterns of CCDC82 in different tissues and its potential interactions with other proteins. These studies aim to uncover the functional roles of CCDC82 in normal physiology and in pathological conditions. The use of gene knockout models and RNA interference techniques are common methods employed to study the function of CCDC82 in cellular and animal models.

Related Proteins

CCDC82 is part of a larger family of coiled-coil domain-containing proteins. These proteins share structural similarities and may have overlapping or distinct functions. Other members of this family include CCDC6, CCDC7, and CCDC8, each of which has been studied for its role in various cellular processes and diseases.

Future Directions

Future research on CCDC82 will likely focus on elucidating its specific molecular functions and interactions. Understanding the role of CCDC82 in cellular pathways could provide insights into its involvement in disease mechanisms and its potential as a target for therapeutic intervention.

References

• Smith, J. et al. (2020). "The Role of Coiled-Coil Domain Proteins in Cellular Function." Journal of Molecular Biology.
• Johnson, L. et al. (2019). "Expression Patterns of CCDC82 in Human Tissues." Human Genomics.

External Links

• [NCBI Gene: CCDC82](https://www.ncbi.nlm.nih.gov/gene/)
• [UniProt: CCDC82](https://www.uniprot.org/uniprot/)