CCRF-CEM
Human cell line used in medical research
Template:Infobox cell line
CCRF-CEM is a human T lymphoblast cell line derived from the peripheral blood of a child with acute lymphoblastic leukemia (ALL). This cell line is widely used in cancer research and drug development due to its well-characterized genetic and phenotypic properties.
History[edit | edit source]
The CCRF-CEM cell line was established in 1964 by researchers at the Children's Cancer Research Foundation (CCRF). The cell line was derived from the peripheral blood of a female child diagnosed with acute lymphoblastic leukemia. Since its establishment, CCRF-CEM has been extensively used in various scientific studies to understand the biology of leukemia and to develop new therapeutic strategies.
Characteristics[edit | edit source]
CCRF-CEM cells exhibit the typical characteristics of T lymphoblasts, including a high nucleus-to-cytoplasm ratio and the presence of surface markers such as CD3, CD4, and CD7. These cells are known for their rapid proliferation and ability to grow in suspension culture. The karyotype of CCRF-CEM cells is complex, with multiple chromosomal abnormalities commonly associated with leukemia.
Applications[edit | edit source]
CCRF-CEM cells are utilized in a wide range of research applications, including:
- Cancer research: Studying the molecular mechanisms underlying leukemia and other cancers.
- Drug development: Screening and evaluating the efficacy of new anti-cancer drugs.
- Genetic studies: Investigating the genetic alterations and pathways involved in leukemia.
Related Cell Lines[edit | edit source]
Several sublines and related cell lines have been derived from CCRF-CEM, including:
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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Contributors: Prab R. Tumpati, MD