CD29

CD29 is a protein that in humans is encoded by the ITGB1 gene. It is also known as integrin beta-1 or fibronectin receptor subunit beta. CD29 is a part of the integrin family of proteins, which are involved in cell adhesion and cell surface mediated signalling.

Function

CD29 is a receptor that binds to extracellular matrix proteins such as fibronectin, collagen, and laminin. It is involved in various cellular functions including cell adhesion, cell migration, cell proliferation, and cell differentiation. CD29 is also involved in various pathological processes including cancer metastasis and inflammation.

Structure

CD29 is a transmembrane protein that consists of a large extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. The extracellular domain of CD29 is responsible for binding to extracellular matrix proteins, while the cytoplasmic tail is involved in intracellular signalling.

Clinical significance

Alterations in the expression or function of CD29 have been associated with various diseases including cancer, fibrosis, and autoimmune diseases. In cancer, increased expression of CD29 has been associated with increased tumor aggressiveness and poor prognosis. In fibrosis, CD29 is involved in the deposition of extracellular matrix proteins, leading to tissue scarring. In autoimmune diseases, CD29 is involved in the adhesion and migration of immune cells, contributing to the pathogenesis of these diseases.

See also

• Integrin
• Extracellular matrix
• Cell adhesion
• Cell migration
• Cell proliferation
• Cell differentiation
• Cancer metastasis
• Inflammation
• Fibrosis
• Autoimmune diseases

References

CD29 Resources
Latest articles Most recent articles Ongoing trials	Wikipedia