CDCA7L

Ideogram human chromosome 7

CDCA7L

CDCA7L is a gene that encodes the Cell Division Cycle Associated 7-Like Protein. This protein is involved in cell division and plays a crucial role in regulating the cell cycle. CDCA7L is essential for proper cell growth and division, and its dysregulation can lead to various diseases, including cancer.

Function

CDCA7L functions as a regulator of the cell cycle, specifically during the G2/M phase transition. It interacts with other proteins involved in cell division to ensure accurate chromosome segregation and cell proliferation. Additionally, CDCA7L is implicated in DNA repair mechanisms, contributing to the maintenance of genomic stability.

Clinical Significance

Mutations in the CDCA7L gene have been associated with certain types of cancer, highlighting its importance in tumorigenesis. Studies have shown that aberrant expression of CDCA7L can promote uncontrolled cell growth and tumor formation. Understanding the role of CDCA7L in cancer development may lead to the development of targeted therapies for these malignancies.

Interactions

CDCA7L interacts with several proteins involved in cell cycle regulation, such as cyclins and cyclin-dependent kinases. These interactions are crucial for coordinating the progression of the cell cycle and ensuring proper cell division. Disruption of these interactions can result in cell cycle defects and genomic instability.