Labetuzumab
(Redirected from CEA-CIDE)
Labetuzumab is a monoclonal antibody designed for the treatment of colorectal cancer. It is developed by Immunomedics, a biopharmaceutical company focused on the development of monoclonal antibody-based products for the targeted treatment of cancer.
Mechanism of Action[edit | edit source]
Labetuzumab works by targeting the CEACAM5 antigen, a cell surface glycoprotein overexpressed in colorectal cancer and other adenocarcinomas. The antibody binds to the antigen, marking the cancer cells for destruction by the body's immune system.
Clinical Trials[edit | edit source]
Labetuzumab has undergone several clinical trials to evaluate its safety and efficacy in treating colorectal cancer. In a Phase II trial, the antibody showed promising results when used in combination with irinotecan, a chemotherapy drug. However, further studies are needed to confirm these findings and determine the optimal dosing regimen.
Side Effects[edit | edit source]
Like all monoclonal antibodies, labetuzumab can cause side effects. These may include infusion reactions, fatigue, nausea, and diarrhea. Patients should be monitored closely for these and other potential side effects during treatment.
Future Directions[edit | edit source]
Research is ongoing to explore the potential of labetuzumab in treating other types of cancer that express the CEACAM5 antigen, such as pancreatic cancer and gastric cancer. The antibody may also have potential in the treatment of metastatic cancer, where it could be used to target cancer cells that have spread to other parts of the body.
See Also[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD