CEACAM5

CEACAM5 or Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 is a protein that in humans is encoded by the CEACAM5 gene. It is a member of the carcinoembryonic antigen (CEA) gene family.

Function

CEACAM5 interacts with other CEACAM members, such as CEACAM1, CEACAM6, and CEACAM7. These interactions can mediate cell adhesion. CEACAM5 is a cell surface glycoprotein that is overexpressed in various human cancers and may play a role in tumor progression.

Clinical significance

CEACAM5 is used as a tumor marker, particularly in colorectal cancer. The protein provides a target for cancer therapy, particularly in gastrointestinal cancers. Elevated levels of this protein can be detected in patient blood and can be used to monitor tumor growth and treatment response.

Structure

The CEACAM5 protein is a single-pass type I membrane protein. It contains one Ig-like C2-type (immunoglobulin-like) domain and two Ig-like V-type (immunoglobulin-like) domains.

See also

• Carcinoembryonic antigen
• CEACAM1
• CEACAM6
• CEACAM7

External links

• CEACAM5 at the US National Library of Medicine Medical Subject Headings (MeSH)

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.