CHD1L
CHD1L
CHD1L (Chromodomain Helicase DNA Binding Protein 1-Like) is a gene that encodes a protein involved in chromatin remodeling and DNA repair processes. This protein is part of the SNF2/RAD54 helicase family and plays a crucial role in maintaining genomic stability.
Function[edit | edit source]
CHD1L is primarily involved in the regulation of chromatin structure, which is essential for various DNA-dependent processes such as transcription, replication, and repair. The protein encoded by CHD1L has ATPase activity, which provides the energy required for chromatin remodeling. This activity allows CHD1L to alter the position of nucleosomes on DNA, thereby facilitating access to the DNA for transcription factors and other proteins involved in DNA repair and replication.
Clinical Significance[edit | edit source]
Mutations or alterations in the expression of CHD1L have been associated with several types of cancer, including hepatocellular carcinoma and breast cancer. Overexpression of CHD1L has been linked to poor prognosis in cancer patients, as it may contribute to increased tumor cell proliferation and resistance to apoptosis.
CHD1L is also implicated in the response to DNA damage. It is recruited to sites of DNA double-strand breaks, where it participates in the repair process. This function is critical for preventing genomic instability, which can lead to cancer development.
Research and Developments[edit | edit source]
Recent studies have focused on understanding the precise mechanisms by which CHD1L contributes to chromatin remodeling and DNA repair. Researchers are also investigating potential therapeutic strategies to target CHD1L in cancer treatment, aiming to inhibit its function and reduce tumor growth.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD