CHMP1B

Ideogram human chromosome 18

CHMP1B

CHMP1B is a protein-coding gene that plays a crucial role in the endosomal sorting complex required for transport (ESCRT) pathway. This gene is located on chromosome 18 in humans and is conserved across various species.

Function

The CHMP1B gene encodes a protein that is a component of the ESCRT-III complex, which is involved in the sorting and trafficking of ubiquitinated proteins for degradation in the lysosome. Specifically, CHMP1B is involved in the final stages of multivesicular body (MVB) formation and the abscission stage of cytokinesis.

Structure

The CHMP1B protein consists of several domains, including an N-terminal MIT domain and a C-terminal helical domain. These domains are essential for its interaction with other ESCRT proteins and for its function in membrane remodeling processes.

Role in Disease

Mutations in the CHMP1B gene have been associated with various diseases, including neurodegenerative disorders and cancer. Dysregulation of the ESCRT pathway, in which CHMP1B plays a critical role, can lead to the accumulation of toxic protein aggregates and impaired cellular homeostasis.

Interactions

CHMP1B interacts with several other ESCRT proteins, such as CHMP4 and VPS4, to facilitate the formation of the ESCRT-III complex. These interactions are essential for the proper function of the ESCRT machinery in cellular processes such as endosomal sorting and cytokinesis.