CIAPIN1

Ideogram human chromosome 16

CIAPIN1

CIAPIN1, also known as Cytokine-Induced Anti-Apoptotic Inhibitor 1, is a protein encoded by the CIAPIN1 gene in humans. This gene is located on chromosome 7 and plays a crucial role in regulating apoptosis, or programmed cell death. CIAPIN1 is involved in various cellular processes, including cell proliferation, differentiation, and survival.

Function

CIAPIN1 functions as an anti-apoptotic protein, meaning it helps prevent cells from undergoing programmed cell death. It interacts with other proteins in the cell to inhibit apoptosis pathways, promoting cell survival. Additionally, CIAPIN1 has been implicated in modulating immune responses and inflammation.

Clinical Significance

Abnormal expression of CIAPIN1 has been associated with various diseases, including cancer. Studies have shown that CIAPIN1 may contribute to tumor growth and resistance to chemotherapy by inhibiting apoptosis in cancer cells. Targeting CIAPIN1 could potentially be a therapeutic strategy for treating certain types of cancer.

Interactions

CIAPIN1 interacts with several proteins involved in apoptosis regulation, such as caspases and Bcl-2 family members. These interactions modulate the balance between cell survival and cell death pathways. Furthermore, CIAPIN1 has been shown to interact with components of the immune system, suggesting a role in immune regulation.