CISH

CISH or Cytokine-inducible SH2-containing protein is a protein that in humans is encoded by the CISH gene. CISH is a member of the Suppressor of cytokine signaling (SOCS) family, a group of proteins known to negatively regulate cytokine signaling.

Function

The CISH gene is induced by cytokines in cells of the immune system. The protein encoded by this gene contains a SH2 domain, which is known to be important in intracellular signal transduction. The protein can bind to the cytokine erythropoietin (EPO) receptor and form a complex with the receptor and JAK2 kinase. It also inhibits the signaling pathway of various cell surface receptors, including the growth hormone receptor, the insulin receptor, and the interleukin-2 receptor.

Clinical significance

Variations in the CISH gene have been associated with susceptibility to infectious diseases, such as tuberculosis and malaria, and autoimmune diseases, such as rheumatoid arthritis.

See also

• Suppressor of cytokine signaling
• Cytokine
• SH2 domain
• Erythropoietin
• JAK2 kinase
• Growth hormone
• Insulin
• Interleukin-2
• Tuberculosis
• Malaria
• Rheumatoid arthritis

External links

• CISH gene at National Center for Biotechnology Information
• CISH protein at UniProt

CISH Resources
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