CLIP (protein)

CLIP (protein)

CLIP (protein) or Class II-associated invariant chain peptide is a protein that in humans is encoded by the CLIP1 gene. It is a molecular chaperone that plays a crucial role in the formation and transport of MHC class II proteins.

Function

CLIP (protein) is a part of the MHC class II protein complex that is expressed on the surface of antigen-presenting cells. It prevents premature binding of peptides to MHC class II molecules before they reach the endosomal compartment where peptide loading is supposed to occur.

Structure

The CLIP (protein) is a small peptide that is derived from the larger Invariant chain (Ii). The Ii is a type II transmembrane protein that is non-covalently associated with the MHC class II alpha and beta chains in the endoplasmic reticulum.

Role in Immune Response

CLIP (protein) plays a crucial role in the immune response. It helps in the presentation of antigenic peptides to the T cells, thereby initiating an immune response.

Clinical Significance

Alterations in the CLIP (protein) can lead to various autoimmune diseases. It has been implicated in diseases like rheumatoid arthritis, multiple sclerosis, and type 1 diabetes.

See Also

• MHC class II
• Invariant chain
• Antigen-presenting cell
• T cell

References

CLIP (protein) Resources
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