CLIP (protein)

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CLIP (protein)

CLIP (protein) or Class II-associated invariant chain peptide is a protein that in humans is encoded by the CLIP1 gene. It is a molecular chaperone that plays a crucial role in the formation and transport of MHC class II proteins.

Function[edit | edit source]

CLIP (protein) is a part of the MHC class II protein complex that is expressed on the surface of antigen-presenting cells. It prevents premature binding of peptides to MHC class II molecules before they reach the endosomal compartment where peptide loading is supposed to occur.

Structure[edit | edit source]

The CLIP (protein) is a small peptide that is derived from the larger Invariant chain (Ii). The Ii is a type II transmembrane protein that is non-covalently associated with the MHC class II alpha and beta chains in the endoplasmic reticulum.

Role in Immune Response[edit | edit source]

CLIP (protein) plays a crucial role in the immune response. It helps in the presentation of antigenic peptides to the T cells, thereby initiating an immune response.

Clinical Significance[edit | edit source]

Alterations in the CLIP (protein) can lead to various autoimmune diseases. It has been implicated in diseases like rheumatoid arthritis, multiple sclerosis, and type 1 diabetes.

See Also[edit | edit source]

References[edit | edit source]


CLIP (protein) Resources

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Contributors: Prab R. Tumpati, MD