COPP

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Classification


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COPP is a chemotherapy regimen used primarily in the treatment of Hodgkin's lymphoma. The acronym COPP stands for the combination of four drugs: Cyclophosphamide, Vincristine (Oncovin), Procarbazine, and Prednisone. This regimen is designed to target and destroy cancer cells while minimizing damage to normal cells.

Components of COPP[edit | edit source]

  • Cyclophosphamide: An alkylating agent that works by interfering with the growth and replication of cancer cells.
  • Vincristine (Oncovin): A vinca alkaloid that inhibits the formation of microtubules, thus preventing cell division.
  • Procarbazine: An alkylating agent that works by inhibiting DNA, RNA, and protein synthesis.
  • Prednisone: A corticosteroid that helps reduce inflammation and suppresses the immune system.

Mechanism of Action[edit | edit source]

The COPP regimen works by combining drugs with different mechanisms of action to enhance the overall effectiveness of treatment. Cyclophosphamide and procarbazine are alkylating agents that damage the DNA of cancer cells, leading to cell death. Vincristine disrupts the mitotic spindle, preventing cell division. Prednisone helps reduce inflammation and can induce apoptosis in certain cancer cells.

Indications[edit | edit source]

COPP is primarily indicated for the treatment of Hodgkin's lymphoma, particularly in cases where other regimens such as ABVD (Adriamycin, Bleomycin, Vinblastine, Dacarbazine) are not suitable. It may also be used in combination with other therapies for certain types of non-Hodgkin's lymphoma.

Side Effects[edit | edit source]

Common side effects of the COPP regimen include:

  • Nausea and vomiting
  • Hair loss
  • Suppression of bone marrow function, leading to anemia, leukopenia, and thrombocytopenia
  • Increased risk of infections
  • Peripheral neuropathy (due to vincristine)
  • Secondary malignancies (long-term risk)

Administration[edit | edit source]

The COPP regimen is typically administered in cycles, with each cycle lasting several weeks. The specific dosing schedule and duration of treatment depend on the individual patient's condition and response to therapy.

Also see[edit | edit source]

Template:Chemotherapy regimens

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Contributors: Prab R. Tumpati, MD