COSMIC

COSMIC (Catalogue of Somatic Mutations in Cancer) is a comprehensive resource that provides detailed information on somatic mutations in human cancer. It is a high-quality curated database that aims to support research in cancer genomics.

Overview

COSMIC is designed to store and display somatic mutation information and related details extracted from scientific literature, as well as from the data generated by the Cancer Genome Project at the Sanger Institute. The database includes information about gene mutations, gene fusions, copy number alterations, and other types of genetic changes that are associated with cancer.

Content

The content of COSMIC is divided into several sections, including:

• Gene Overview: This section provides a summary of the gene, including its name, synonyms, and a brief description of its function and role in cancer.
• Mutation Overview: This section provides a summary of the mutations found in the gene, including the types of mutations and their frequencies.
• Tissue Distribution: This section provides information on the tissues in which the gene's mutations have been found.
• Mutation Distribution: This section provides information on the distribution of the gene's mutations across different types of cancer.

Access

COSMIC is freely accessible to academic researchers. Commercial users are required to obtain a license.

See also

• Cancer Genome Project
• Sanger Institute
• Cancer genomics

COSMIC Resources
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