CPEB1

Ideogram human chromosome 15

CPEB1

CPEB1, also known as Cytoplasmic Polyadenylation Element Binding Protein 1, is a protein that plays a crucial role in the regulation of gene expression. It is a member of the CPEB family of RNA-binding proteins and is involved in the control of mRNA translation and stability.

Structure

CPEB1 is composed of several functional domains, including RNA-binding domains and protein interaction domains. These domains allow CPEB1 to interact with specific RNA sequences and other proteins involved in the regulation of gene expression.

Function

CPEB1 functions primarily in the cytoplasm of cells, where it binds to specific sequences in the 3' untranslated regions (UTRs) of target mRNAs. By binding to these sequences, CPEB1 can regulate the translation of the mRNA into protein and control its stability. One of the key functions of CPEB1 is its role in the process of cytoplasmic polyadenylation. This process involves the addition of poly(A) tails to the 3' end of mRNAs, which can influence their translation and stability. CPEB1 helps to regulate this process by binding to cytoplasmic polyadenylation elements (CPEs) in the mRNA and recruiting other proteins involved in polyadenylation.

Regulation

The activity of CPEB1 is tightly regulated in cells to ensure proper control of gene expression. Various signaling pathways and post-translational modifications can influence the function of CPEB1, allowing cells to respond to different stimuli and environmental conditions.

Role in Development and Disease

CPEB1 has been implicated in various biological processes, including embryonic development, synaptic plasticity, and cell cycle regulation. Dysregulation of CPEB1 has been associated with several diseases, including cancer and neurological disorders.

See also

• Cytoplasmic polyadenylation element binding protein
• Gene expression regulation
• RNA-binding proteins